Ping-Jyun Sung, 宋秉鈞

博士 / 國立中山大學 / 海洋資源學系研究所 / 89 / In our continuing research on the cytotoxic constituents of Taiwanese gorgonian corals, the EtOAc extracts of Briareum excavatum (Nutting) and Junceella fragilis (Ridley) were investigated, repectively. Twenty-four compounds, excavatolides D (1), F-K (2-7), M (8), U-Y (9-13);briaexcavatolides D (14), K (15), L (16), O(17), P (18); excavatolides B (19), C (20), E (21); briaexcavatolides B (22), C (23), and (1S*,2S*,5Z,7S*,8S*,9S*,10S*11R*,12R*,13Z,17R*)-2,12-diaceto...

Kun-Ming Kuo, 郭坤銘

碩士 / 國立中山大學 / 海洋生物研究所 / 89 / The recruitment, growth rate and survival of every juvenile corals on artificial substrates, deployed every 2 months since September 1998, for a total of 6 times, were investigated every 2 months, from November 1998 to September 2000, at Nanwan, southern Taiwan. The influence of season and habitat (e.g., new vs. old substrate and different positions etc.) on the above life history characteristics were the foci of this study. Coral recruitment during the 2-year period...

Hung-Tse Huang, 黃宏澤

碩士 / 國立高雄海洋科技大學 / 水產食品科學研究所 / 95 / Lectins, the carbohydrate glycosylated with peptides or proteins, can bind to other glycans attached to glycoproteins, glycolipids, or polysaccharides with high affinity. Lectins can also bind to the erythrocytes, normal or transformed cell, to cause agglutination. The lectins exist widely in nature, such as in plant, vertebrate and invertebrate. This study is focus to the isolation, characterization of anti-tumor activity by Pleurotus citrinopileatus sing. lec...

Yu-Pei Chen, 陳玉珮

碩士 / 國立中山大學 / 海洋資源學系研究所 / 93 / In connection with our long-standing interest in the chemical constituents of Formosan octocorals, we have investigated the octocorals Briarium excavatum and Junceella fragilis, collected at southern Taiwan coast. During the investigation, four new metabolites brianthiens D‐G (1‐4), have been isolated from Briareum excavatum. In addition, four 11,20-epoxybriaranes including three new metabolites, fragilides B‐D (5‐7), along with a known briarane (–)-11α,20α-epoxy-...

Kuang-Chih Hung, 洪廣智

碩士 / 國立中山大學 / 海洋資源學系研究所 / 88 / Abstract The n-hexane extract of Formosan gorgonian coral Isis hippuris (Isididae) collected from Green Island was found to exhibit significant cytotoxicity against P-388, A-549 and HT-29 cell lines. Cytotocicity-guided fractionation of this extract led to isolation of a known subersenone (1), five new suberosanane analogues, suberosanone (2), suberosenol A (3), suberosenol B (4), suberosenal A acetate (5) and suberosenol B acetate (6), two sesquiterpenes of novel ...

Tseng, li-chun, 曾立鈞

碩士 / 國立海洋大學 / 海洋生物研究所 / 86 /

YAN, JIN-FENG, 顏金鳳

碩士 / 高雄醫學院 / 藥學研究所 / 77 /

Huei-Cyun Huang, 黃惠群

碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 103 / Soft corals of the genus Sinularia and Clavularia were found to rich sources for secondary metabolites of different skeletons and biological activity. In the course of our studies on secondary metabolites from marine organisms, the acetone-solubles of the Formosan octocoral Sinularia erecta collected at Penghu has led to the isolation of a new cyclic peroxide-containing sesquiterpene, sinularioperoxide F (1), a new nor-monoterpene, sinuladione (2), two novel ...

Wan-ru Tseng, 曾琬茹

碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 103 / Marine invertebrates have been found to be a rich source of bioactive secondary metabolites. In order to discover bioactive compounds, we have studied the chemical constituents from the organic extracts of two Formosan soft corals, Klyxum flaccidum and Lobophytum michaelae. The study on the chemical constituents of the acetone extract of Klyxum flaccidum has led to the isolation of five new natural products, including three steroids (1–3) and two cembrene-typ...

I-Lun Tsai, 蔡依倫

碩士 / 國立屏東科技大學 / 森林系 / 93 / The majority of green plants are autotrophic, in which they have the ability to obtain energy through indigenous photosynthesis. However, there are many groups of land plants are achlorophyllous and heterotropic (i.e. non-photosynthetic). We would like to examine the presence of plastid genome in one of the non-photosynthetic plants, Galeola lindleyana, of Orchidaceae. My thesis is to use degenerate primers to amplify DNA fragments from plastids, and selected nuclear a...

Shin-Yi Lin, 林欣儀

博士 / 國立中興大學 / 食品暨應用生物科技學系所 / 104 / Ergothioneine is a sulfur containing amino acid that functions as an oxidative damage and anti-inflammation in organisms. Ergothioneine is produced only by fungi and few mycobacteria. It cannot be biosynthesized in human body, and is only ingested from dietary sources. Mushrooms are a primary source of ergothioneine, especially the Pleurotus spp. Pleurotus citrinopileatus (golden oyster) is an edible mushroom, also known as Yu-huang-mo in Chinese. Many reports ...

Shwu-Li Wu, 吳淑黎

博士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 96 / In order to search for bioactive compounds, we have studied the chemical constituents from the organic extracts of one soft corals Klyxum simplex and two gorgonians Subergorgia mollis and Briareum excavatum. This study had led to the isolation of twenty-seven natural compounds 1–27, including nineteen new eunicellin–type diterpenoids, simplexins A–S (1–19) from K. simplex, one new steroid 11α,15α-diacetoxy-17β-pregna-4,20- dien-3-one (20) along with one known ...

Yu-fang Lin, 林妤芳

碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 96 / We have searched the bioactive metabolites from the wild-type and cultured soft corals Sinularia flexibilis. This study led to the isolation of fifteen natural products (1–15), including four new metabolites (1–4), flexibilisolide A (1), flexibilisin A (2), quercifomolide D (3) and quercifomolide B (4) along with eight known compounds (5–12) from the wild-type soft coral S. flexibilis, and three new metabolites (13–15), flexibilisolide B (13), flexibilisin B (...

Shi-Ying Huang, 黃世英

碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 96 / Lemnalol (8-isopropyl-5-methyl-4-methylene-decahydro-1, 5-cyclo-naphthalen- 3-ol) is a natural compound isolated from the marine soft coral Lemnalia cervicorni. In the present study, we focused to determine whether lemnalol has in vivo antinociceptive and anti-inflammatory effects on carrageenan-induced rat paw edema and the hyperalgesia model using the thermal hyperalgesia test, paw edema assay, and histological examination. Furthermore, we also explored th...

CHING-LI LO, 羅清利

碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 96 / The chemical constituents of organic extracts of the Formosan soft corals Sinularia sp. and Sinularia lochmodes were studied. Investigation on Sinularia sp. has led to the isolation of eight compounds (1-8), including four new compounds, 1α,3β-dihydroxy-24S-methylcholesta-5,9-diene (1), 1α,3β-dihydroxy-24-methylencholesta-5-ene (2), 1α,3β-dihydroxy -24S-methylcholesta-5-ene (3), sinularioperoxide E (4), and four known compounds, 7-isopropenyl-1,4a-dimethyl-dec...

Yun-hsuan Huang, 黃筠軒

碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 104 / The study was to isolate and elucidate bioactive secondary metabolites from the organic extracts of three Formosan soft corals. Chromatographic fractionation of organic solubles of Sarcophyton trocheliophorum collected at Penghu led to the isolation of five new compounds (1–5) as well as seven known cembranoids sarcophytonin F (6), sarcophytoxide (7), laevigatol A (8), sarcophytonin C (9), sarcophytoninG (10), 17-hydroxysarcophytoxide (11), and lobophynin B (...

Yao-Li Yun, 雲曜立

碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 104 / Natural product scientists have reported many secondary metabolites containing sesquiterpenoids and cembranoids from soft corals Lobophytum spp., Sacrophyton spp., and Sinularia spp., and further search for new compounds with biological activity. In this report, we focused on marine natural product extraction and separation studies, purified by various chromatographic techniques, isolating thirteen compounds from the soft corals Sinularia leptoclados, Sacroph...

Yi-ying Huang, 黃怡瑛

碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 101 / Marine invertebrates have been found to be a rich source of bioactive secondary metabolites. Soft corals of the genus Sinularia, Lobophtum, and Clavularia were found to possess different skeletons secondary metabolites. Therefore we have investigated the secondary metabolites of the soft corals Sinularia leptoclados, Lobophtum crassum, and Clavularia viridis. Investigations on the chemical constituents of S. leptoclados collected at Dongsha Atoll of the South...

劉筱瑜

碩士 / 國立中山大學 / 海洋資源學系 / 85 / Five briarein diterpenes had been isolated from the Kenting gorgonian Briareum excavatum, four of them were known compounds and one of them was a new briarein containing a chlorine atom. They were (1R*, 2R*, 3R*, 5Z*, 7S*, 8S*, 9S*, 10S*, 11R*, 12S*, 14S*, 17R*)-2,9,14-triacetoxy-3-butyryloxy-8,17-epoxy-12-hydroxybriara-5-en-19-one (1), (1R*, 2R*, 3R*, 5Z*, 7S*, 8S*, 9S*, 10S*, 11R*, 12S*, 14S*, 17R*)-2,3,9,14-tetraacetoxy-8,17-epoxy-12-hydroxybriara-5-en-19-one (2), ...

謝珮文

碩士 / 高雄醫學大學 / 藥學研究所 / 81 / As a result of our search for biologically active substances from marine organisms, the methanolic extract of the marine Formosan soft corals, Sarcophyton trocheliophorum and Sinularia sp., were found to show significant cytotoxicity against in. vitro tissue culture cells in human KB, A-549 lung carcinoma, HT-29 colon tumor and HL-60 human promyelocytic leukemia, as well as in murine P-388 lymphocytic leukemia and antiplatelet aggregation activity against in vitro coll...

Yen-Ju Tseng, 曾彥儒

博士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 98 / In order to search for bioactive compounds, we have studied the chemical constituents from the organic extracts of five soft corals including Sinularia lochmodes, Sinularia nanolobata, Sinularia grandilobata, Sinularia depressa and Lobophytum crassum. This study had led to the isolation of eighteen natural compounds 1－18, including seven new compounds, lochmolins A － G (1 － 7) from S. lochmodes, a new compound nanolobatolide (8) featuring with a new carbon ske...

Guan-syuan Huang, 黃冠瑄

碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 98 / In recent years, marine natural products in drug development increasingly wide range of applications. Both Taiwan''s geographical location and climate are creating a rich marine biodiversity. Hence there is needed to construct a marine natural product database which with Taiwan features. The goal of this study is to establish a Taiwan''s marine natural product database, with preliminary collected Formosan soft coral diterpenoids natural pro...

Bo-RenWang, 王伯仁

碩士 / 國立成功大學 / 地球科學系碩博士班 / 98 / To understand the behavior of uranium-series isotopes in diagenetically-altered fossil corals, this study collected fossil corals from Kenting, Heng Chun Peninsula, Taiwan. After separating each coral sample into 3-5 sub-coral samples, we measured the distributions of uranium (238U, 234U) and thorium (230Th, 232Th) isotopes in each of these subsamples. Results show that the modern and unaltered corals collected from Eruanbi (鵝鑾鼻) at modern sea-level have 238U activ...

Su-fen Chiu, 邱素芬

博士 / 國立中山大學 / 生物科學系研究所 / 98 / The methods of denaturing gradient gel electrophoresis (DGGE) and DNA sequencing were used to analyze the ribotypes of microbial communities associated with corals. Both healthy and diseased coral of different species were collected at three locations off the southern coast of Taiwan. Ribotyping results suggested that the microbial communities were diverse. The microbial community profiles, even among the same species of corals from different geographical locations ...

Guey-Horng Wang, 王貴弘

博士 / 國立中山大學 / 海洋資源學系研究所 / 90 /

Chin-hsiang Chang, 張晉祥

碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 95 / Chromatographic separation of acetone/methylene chloride extracts of Formosan soft coral Capnella imbricata (GN75) led to the isolations of six new capnellenes, 8b,10a-diacetoxy-D9(12)-capnellene (1), D9(12)-capnellene-5b,8b,10a-triol (3), D9(12)-capnellene-8b,10a,13b-triol (4), 8b-acetoxy-D9(12) -capnellene (7), D9(12)-capnellene-8b,14b-diol (8), D9(10)-capnellene-12-ol-8-one (9), and three known compounds, D9(12)-capnellene-8b,10a-diol (2), D9(12)-capnellene...

Jui-hsin Su, 蘇瑞欣

博士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 94 / In order to discover and develop new drug from soft corals and gorgonian corals of Taiwan, we have searched the bioactive metabolites from the organic extracts of three soft corals Nephthea chabrolii, Sinularia manaarensis, Sinularia leptoclados, and one Gorgonian of Briareum genus. This study had led to the isolation of fifty-five natural products (1–55), including seventeen new meroditerpenoid-related metabolites (1–7 and 9–18), two new C18 terpenoid–related...

Guo-Lin Tzeng, 曾國琳

碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 94 / Three new sesquiterpene compounds were isolated from the extract of soft coral Xenia sp. collected at Green Island in Taiwan. 8-epi- xenitorin A (1) is a cadinane skeleton compound which consists of two 6 membered-ring, three methyl groups, two double bonds and a secondary hydroxyl group；10-epi-xenitorin C (2) is a cadinane skeleton compound which comprises two 6 membered-rings, three methyl groups, two double bonds and a tertially hydroxyl group；7-isopro...

Jiunn-Chin Chiou, 邱俊欽

碩士 / 國立中山大學 / 海洋資源學系 / 87 / Chromatographic purification of a cytotoxic chloroform extract of Formosan soft coral Sinularia granosa (collected in Green Island) led to the isolation of two known norcembrane norditerpenoids, (1R*, 5S*, 8R*, 10S*, 11R*)—11—hydroxy—1—isopropenyl—8—methyl—3, 6—dioxo—5, 8—epoxy—cyclotetradec—12—ene—10, 12－carbolactone (45) and (1R*, 5S*, 8R*, 10S*, 11S*)—11—hydroxy—1—isopropenyl—8—methyl—3, 6—dioxo—5, 8—epoxy—cyclotetradec—12—ene—10, 12－carbolactone (46). P...

Yin-di Su, 蘇尹帝

博士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 104 / Studies on the secondary metabolites of the octocoral Briareum sp. collected off the coast of Southern Taiwan had led to the isolation of twenty-four new briarane analogues, including briarenolides H–Y (1–18) and ZI–ZVI (19–24), along with thirteen known compounds, briaexcavatolides H (25), F (28), G (29), P (32), solenolides A (26), C (27), brianolide (30), briaexcavatins P (31), K (34), N (35), excavatolides M (33), Z (36), and 2β-acetoxy-2-(debutyryloxy) s...

E-Ping Chiu, 邱怡萍

碩士 / 國立中山大學 / 海洋資源學系研究所 / 92 / Chromatographic separation of methylene chloride extracts of Formosan soft coral Lemnalia laevis, Thomson and Dean (collected at Green Island off Taiwan) led to the isolation of eight sesquterpenoids and three norsesquterpenoids compounds, 4(S＊)-acetoxy,10(S＊)-hydro xy,5-oxo,1(S＊),12(S＊)neolemna-2(Z),8-diene (1)、4(S*)-acetoxy,10,5-oxo, 1(S*),12(S*)neolemna-1(Z),8-dieme (2)、(6�圁),1(10)-epoxy-2-hydroxy -12-nornadosin-7,11-dione (3)、(6�浶),1(10)-epoxy-2-hydroxy-12- nor...

Pei-Ying Sung, 宋佩盈

碩士 / 國立中山大學 / 海洋資源學系研究所 / 90 / Chromatographic separation of methylene chloride extracts of Formosan soft coral Lemnalia cervicorni May (collected at Green Island off Taiwan) led to the isolation of four ylangene sesquiterpenoids, GN40-29 (1), GN40-79 (3), GN40-169 (4), and GN40-173 (5). Acetylation of GN40-29 (1) gave a derivative GN40-29a (2). Compounds 3-5 were new compounds. Compound 1 showed cytotoxicity against HT-29 cell, while compound 5 was cytotoxic to P-388 cells. The methylene chlori...

Tsai, Pin-Hsuan, 蔡品萱

碩士 / 國立臺灣海洋大學 / 海洋環境與生態研究所 / 107 / Sex change phenomenon is defined as the cases where an individual reproduces only as one sex during one breeding season or episode, and as the other sex during another. Sex change is considered as a reproduction strategy that allows the animals to maximize their reproductive success and their genetic contribution to next generation. To date, sex change has been found in a variety of animals across taxa such as teleost fish, sponges, flatworms, nematodes, anneli...

Jia-Yan Chen, 陳佳言

碩士 / 大仁科技大學 / 製藥科技研究所 / 101 / The aim of this research was to assess the blood lipids modulating functions of the compounded preparations which are composed mainly of Eucheuma (Eucheuma okamurai Yamada ), Siberian Ginseng (Eleutherococcus senticosus ) and Yam (Dioscorea opposite ) with different ratios. The hypolipidemic effects were initially assessed using a 3T3-L1 cell (a murine pre-adipocytes cell line) model. The results demonstrated significant inhibition on the lipid droplets accumulation...

Che-hung Lin, 林哲宏

碩士 / 國立中山大學 / 海洋生物研究所 / 95 / Three brooding corals, Seriatopora hystrix, Stylophora pistillata, and Pocillopora damicornis in Nanwan Bay, southern Taiwan, revealed a diel rhythm of larval release. Planulation by S. hystrix and S. pistillata was highly synchronized with one peak of planula release occurring close to sunrise. Planulae of P. damicornis were released throughout the day with two peaks occurred in the early morning and at night. We maintain corals in laboratory with varied light-dark ...

Bo-Yuan Chen, 陳柏元

碩士 / 國立東華大學 / 海洋生物科技研究所 / 98 / In the continuing search for novel substance from marine invertebrates originally distributed in Taiwan waters. The octocoral Briareum excavatum was transplanted to the culturing tanks located in National Museum of Marine Biology & Aquarium (NMMBA) for its interesting chemical constituents. This study had led to the isolation of nine briarane derivatives, including seven new compounds excavatoids E−K (1−7), and two known metabolites, excavatolide X (8) and briaexca...

Hwang, Keh-Lih, 黃克莉

碩士 / 國立海洋大學 / 海洋生物研究所 / 88 /

Shin-Pin Chen, 陳世斌

碩士 / 國立中山大學 / 海洋資源學系研究所 / 89 / Abstract In our continuing studies on the chemical constituents of Taiwanese octocorals, the gorgonian coral Isis hippuris and the sea pen coral Virgularia juncea, which were collected from the coast of Green Island and Peng-Hung Islands, respectively, have been the subjects of our investigations. Six compounds, including two new steroids, hippuristerones A and E (1 and 2), along with three known steroids 3β-hydroxy-5α-pregnan -20-one (3), prenga-4-ene-3,20-d...

Wu, Cheng Shi, 吳誠十

碩士 / 國立臺灣大學 / 海洋研究所 / 82 /

Huang, Xing Zhuo, 黃興倬

碩士 / 國立臺灣大學 / 海洋研究所 / 82 /

古皓東

碩士 / 國立嘉義大學 / 森林暨自然資源學系研究所 / 102 / This study focused on spatial patterns of recruitment in the Kenting karst forest. Our study site in the Kenting coral reef reserved area witch located in southern Taiwan. This plot established 6 ha in 1996, completed 10 ha in 2001 and finished first review in 2008. We recorded 39,093 individuals of 95 species in 2008, including 74 genus and 34 families, and the tree structure based on DBH 5 to 10 cm. The topography is fairly rugged in our plot because of the w...

Chih-Lin Tseng, 曾智麟

碩士 / 國立中山大學 / 海洋生物研究所 / 93 / The maximum quantum yield (Fv/Fm), zooxanthellae density, chlorophyll a concentration and protein concentration of non-bleached and bleached colonies of the reef coral Acropora intermedia were measured in inlet of The Third Nuclear Power Plant of Nanwan Bay in southern Taiwan. A significant positive correlation was found between Fv/Fm and chlorophyll a concentration per zooxanthellae of non-bleached colonies. The chlorophyll a concentration per zooxanthellae and zoox...

Hsu, Chih-Hung, 徐志宏

碩士 / 國立海洋大學 / 海洋生物研究所 / 86 /

Yuan-Hua Chang, 張原華

碩士 / 國立中興大學 / 食品暨應用生物科技學系所 / 103

LIU,MING-QIN, 劉銘欽

碩士 / 國立中山大學 / 海洋生物研究所 / 78 /

HUANG, YI-XUN, 黃沂訓

碩士 / 國立臺灣大學 / 海洋研究所 / 74 /

Lin, Yih Cheng, 林益正

碩士 / 國立中山大學 / 海洋生物研究所 / 81 / There are major differences in reproductive modes between Euphyllia ancora and E.glabrescens. E.ancora is a gonochoristic species, which broadcasts gametes during a short spawing season E. glabrescens is hermaphroditic and broods larvae during extended season. Horizontal starch gel electrophoresis was used to investigate the population genetic variation of the two her...

Ying-Pin Wang, 王盈斌

碩士 / 國立東華大學 / 海洋生物多樣性及演化研究所 / 97 / In order to understand the interactions between picoeukaryote and scleractinian corals, we investigated the ability of scleractinian corals to remove these small particles, as well as measuring the growth rates of coral, and to determine the effect of coral exudation on picoeukaryote growth. Experiments were conducted by adding cultured picoeukaryote (~1.6μm) to S. pistillata (SP), M. stellata (MS), and control tanks, respectively. The results showed that withi...

Yeh, Chang Ho, 葉昌河

碩士 / 台北醫學院 / 藥學研究所 / 85 / Tannins are polyphenolic compounds which widely exist in plant kingdom. Recently, their characteristics have been realized together with developmentof chromatography techniques and spectrascopic analysis. The bioactivitiesof polyphenolic compounds also have been reported successively. Thus, tanninchemistry is a new research field of natural products. Red guava, a variant of Psid...

Chih-Hua Chao, 趙子華

碩士 / 國立中山大學 / 海洋資源學系研究所 / 91 / Several terpenoids isolated from a Formosan gorgonian coral Isis hippuris have shown significant cytotoxic activity against various cancer cell lines. In our studies, the EtOAc and n-Hexane extracts showed potent cytotoxic response toward P-388, A549 and HT-29 cancer cell lines. In order to search other active components, we have studied the chemical constituents of I. hippuris from a Green Island specimen. Thus, the investigation on the chemical content of this ex...