Schermelleh, Lothar

Uncovering the motifs of a higher order nuclear architecture and its implications on nuclear function has raised increasing interest in the past decade. The nucleus of higher eukaryotes is considered to display a highly dynamic interaction of DNA and protein factors. There is an emerging view that there are hierarchical levels of gene regulation, reaching from epigenetic modifications at the DNA- and histone level to a higher order functional nuclear topology, in the context of which gene-activa...

Marandi, Nima

Im Verlaufe der zellulären Reifung wandern (migrieren) unreife Nervenzellen von der Germinalschicht in ihre Zielschicht, in der sie nach dem Auswachsen von Dendriten synaptische Verbindungen bilden. Diese Reifungsprozesse gehen mit Anstiegen der intrazellulären Kalziumkonzentration, sogenannten Kalziumsignalen, einher. Während die Neurotransmitter GABA und Glyzin Nervenzellen des adulten Gehirns hyperpolarisieren und dadurch Aktivität hemmen, depolarisieren si...

Meiser, Andrea

Das Modifizierte Vaccinia Virus Ankara ist ein hoch attenuierter Vaccinia Virus Stamm, der waehrend des Pockenausrottungsprogramms der WHO entwickelt wurde. Heute gewinnen attenuierte Pockenviren zunehmend Bedeutung als Lebendvaccinen gegen verschiedene Infektionskrankheiten und in der Krebstherapie.
Das Ziel dieser Arbeit war einen rekombinanten viralen Vektor auf MVA-Basis zu entwickeln, welcher Fremdantigene auf der Oberflaeche der extrazellulaeren, behuellten Viruspartikel (EEV) prae...

Besir, Christina

Im Rahmen dieser Arbeit wurde zum ersten Mal die PKC-vermittelte Inhibition der EGF-induzierten JNK-Aktivität durch GPCRn gezeigt, die durch Transmodulation des EGF Rezeptors verursacht wird. Darüber hinaus wurde anhand einer dominant negativen Mutante der Effekt von PKD auf diesen Prozess nachgewiesen und ihre Rolle in der bereits durch (Bagowski et al., 1999) beschriebenen PDGF-vermittelten JNK-Inhibition verifiziert.
Weiterhin wurde gezeigt, dass die Liganden Endothe...

Reindl, Christiane Simone

In der Arbeit wurde die Methodik einer Kombination aus einer Immunzytochemischen Färbung und Fluoreszenz-in-situ-Hybridisierung (FISH) mit Sonden für 6p, 8p und 8q an Interpahsezellen etabliert. Anschließend erfolgte die Analyse von Tumorzelllinien und Primärkulturen, die aus Knochenmarkaspiraten von Patienten mit Prostatakarzinom gewonnen worden waren. Sowohl in den Zelllinien wie auch in den Primärkulturen der disseminierten Prostatakarzinomzellen w...

Grasbon, Jan Felix

Die sprunghafte Entwicklung in der Femtosekundenlasertechnologie Anfang der 90er
Jahre ermöglicht es, laserphysikalische Experimente in den verschiedensten Bereichen
der Naturwissenschaften bei Pulsdauern von einigen Femtosekunden und elektrischen
Feldstärken in der Größenordnung inneratomarer Felder durchzuführen. Im Rahmen dieser
Arbeit wurden die drei wichtigsten Prozesse im Bereich der Wechselwirkung von
Ato...

Guthoehrlein, Gerhard Robert

Ziel der hier vorliegenden Arbeit war es, ein einzelnes in einer Ionenfalle gespeichertes
Kalziumion als Meßsonde fuer das elektromagnetische Feld eines optischen
Resonators zu verwenden. Bei einer Anregungswellenlaenge von 397 nm konnte das
Feld mit einer Aufl¨osung von 60 nm unterhalb der Beugungsgrenze vermessen werden.
Die untere Grenze der Aufloesung wird bei Verwendung eines gespeicherten
Ions nur durch die Ausde...

Terzic, Aleksandra

Die cDNA des Hic2-Gens kodiert wie Hic1 und �^FBP (Huhn) ebenfalls fünf C2H2 Zink-Finger des Krüppel-Typs. Im Vergleich der ermittelten Hic2-Sequenz mit verschiedenen Proteinsequenzen homologer Proteine aus verschiedenen Spezies (HIC1, Hic1, HIC2, �^FBP, sowie ein hypothetisches Protein) zeigt Hic2 über 80% Homologie zu HIC1 im Bereich der BTB/POZ- und Zink-Finger-Domänen. Darüber hinaus besitzen beide Proteine identische GLDLSKK/R-Motive.
Inn...

Netz, Astrid

1. Propargylkationen - Erzeugung, Struktur und Reaktivität
In Anlehnung an die literaturbekannte Addition [71] eines Lithiumacetylids an ein
Aldehydderivat werden unter zusätzlicher Chromtricarbonylaren-Komplexierung diastereomerenreine
Substratvorläufer 91 erhalten.
Mit dem Ziel, die relevanten Einflußfaktoren und Stabilisierungsmechanismen für eine stereo-
und regioselektive kationische Propargylierungsreaktio...

Bültmann, Andreas

Die Expression des HIV-1 Env Glykoproteins wird von verschiedenen Faktoren beeinflußt,
die sowohl auf die Env mRNA als auch auf das Glykoprotein wirken. Diese Faktoren
verursachen eine sehr effiziente Suppression des Glykoproteins, weshalb nur ein geringer
Anteil von Env auf der Zelloberfläche exprimiert wird, während der größte Teil im
Endoplasmatischen Retikulum (ER) zurückgehalten und nachfolgend degradiert ...

Müller, Irina

Melendez, Barbra Sue

The ability to rapidly and accurately perform sensitivity analysis in military deployment planning is a vital tool for force deployment planners. The Deployment Scheduling Analysis Tool (DSAT), a new software tool, provides this ability. DSAT builds the deployment scenario through a graphic user interface, invokes an adaptation of the Virtual Factory to schedule the movement and delivery of the equipment and provides meaningful output in the form of reports and graphics. The Virtual Factory is a...

Newton, Leslie Phelps

A thinning and fertilization study was installed on a 7-year-old naturally regenerated hardwood stand on somewhat poorly drained soils in the Atlantic Coastal Plain of North Carolina (Northampton County). Dominant species were sweetgum (<i>Liquidambar styraciflua</i> L.) and red maple (<i>Acer rubrum</i> L.). Treatments were thinning (to 3000 stems per hectare in February 1997) and fertilization (238 kg/ha N and 58 kg/ha P hand broadcast in...

Molina, Jonathan Rueda

<html><head><meta http-equiv="Content-Type" content="text/html; charset=windows-1252"><meta name="Generator" content="Microsoft Word 97"><meta name="GENERATOR" content="Mozilla/4.77 [en] (Windows NT 5.0; U) [Netscape]"><title>Introduction</title></head><body text="#000000" link="#0000FF" vlink="...

Gayo, Javier

GAYO, JAVIER. Software Analysis Techniques for Odor Analysis and ClassificationUsing the Electronic Nose. (Under the direction of Dr. Susan M. Blanchard and Dr. S.Andrew Hale.)<br><br>The objectives of this thesis were to compare methods of feature extraction and data classification used in electronic nose. The NC State electronic nose (e-nose) was used to discriminate between SkipJack tuna (<I>Katsuwonus pelamis</I>) samples cooked at thre...

Hasse, Eleanor Enthoven

ABSTRACTHASSE, ELEANOR ENTHOVEN. Reform in Biology Education: Teachers Implementation of a New Biology Curriculum. (Under the direction of Glenda Carter.)Biology: A Community Context (BACC) (Leonard & Penick, 1998) is a National Science Foundation funded high school biology curriculum designed to meet the goals of the reform movement in science education as envisioned in the National Science Education Standards (National Research Council, 1996) and the Benchmarks for Science Literacy (Am...

McNatt, Regan Allison

As eutrophication of coastal waters increases, water quality issues such as hypoxia have come to the forefront of environmental concerns in North Carolina. Many fisheries in North Carolina are dependent on estuaries for essential nursery habitat. Chronic hypoxia during the summer has become a common occurrence in North Carolina estuaries, increasing the exposure of juvenile fish to hypoxic conditions.I conducted a laboratory study to investigate how various degrees of hypoxia affect growth rates...

Rhea, Anisa Clair

RHEA, ANISA CLAIR. The Individual, Institutional, and Interactional Influences on Women s Decisions to Have a Child: A Multi-Level Examination. (Under the Advisement of Catherine Zimmer.)Using data from Waves 1 and 2 of the National Survey of Families and Households (NSFH), I independently and aggregately examine multi-level predictors (individual, institutional, and interactional) of married women s decisions to have a child. The individual level consists of normative childbearing consideration...

Shelby, Jennifer Duvall

AbstractShelby, Jennifer Duvall. Evaluation of Hydrology and Water Quality in a Large Watershed in North Carolina s Lower Coastal Plain Following the Hurricanes and Related Storms of 1999. (under the direction of Dr. R. W. Skaggs and Dr. G. M. Chescheir)Quantifying and recording the impacts of large storm events is important to watershed management. Large concentrations of nutrients and pollutants may be lost from a watershed in runoff during these events.This project documents the hydrologic an...

Calantoni, Joseph

Predicting the evolution of nearshore bathymetry from the highest uprush of the swash offshore to the location of wave breaking is a difficult problem of significant importance, with economic, legal, engineering, scientific, and military implications for coastal environments. Despite the apparent accessibility of the phenomena of interest, namely, the motion of sand under the forcing of waves and currents, the predictive capability of existing models for nearshore evolution is poor. A detailed s...

Hilderbrand, Douglas Clarence

Previous tropical cyclone risk assessment studies have been national in scope. This study demonstrates the need for regional risk assessments, using the tropical cyclone history of North Carolina as an example. The standard normalization procedure for historical damage data was reevaluated. A housing factor was used instead of the more conventional population factor to go along with inflation and changes in wealth. For coastal counties in North Carolina, housing figures from 1940-2000 increased ...

Neal, Jason Wesley

NEAL, JASON WESLEY. Live Fast and Die Young: On the Growth and Mortality of Largemouth Bass in Puerto Rico. (Under the direction of Dr. Richard L. Noble)Largemouth bass (Micropterus salmoides) have been widely introduced into freshwater systems around the world. In Puerto Rico, this species presents a management challenge to natural resource agents who wish to promote it as a sportfish because growth and survival are unlike that observed in its native temperate regions. Juvenile growth is linear...

Pritzl, T. Jane

ABSTRACTPRITZL, THELMA JANE. The Effect of Experimentally Enhanced Daydreaming on an Electroencephalographic Measure of Sleepiness. (Under the direction of Dr. James W. Kalat and Dr. Slater E. Newman.)Experimental evidence suggests that REM dreaming and daydreaming are related on a neuropsychological level. There is also suggestive experimental evidence that dreamlike mentation may serve to partly compensate for accumulated REM sleep need. The present study tested the hypothesis that daydreaming...

McCarthy, Annette

Estuaries are complex ecosystems that are composed of a number of sensitive and inter-dependent environments. An abundance of nutrients combine with the dynamic conditions to create some of the most productive environments on the planet. Almost 85% of the commercially harvested fish in the United States depend on estuaries and the surrounding coastal waters at some stage in their life history. Many estuarine drainage basins contain large quantities of agricultural acreage. Over 29 million pounds...

Reeves, Heather Dawn

The effects of latent heating on frontal speed are investigated. It is conjecturedthat the existence of prefrontal latent heating leads tofaster translation speeds and that the development oflatent heating in the prefrontal zone can lead to frontalacceleration. A case study of a cold front where the attendingprecipitation band propagated into the prefrontal zone is presented.This front accelerated at the same time the precipitation moved into theprefrontal zone. Through inspection of the potenti...

Betancourt, Doris Alicia

BETANCOURT, DORIS ALICIA. Characterization of diazotrophs containing Mo-independent nitrogenases from diverse natural environments. (Under the direction of Paul E. Bishop.)Our laboratory was the first to identify the presence of Mo-independent nitrogenases in Azotobacter vinelandii and in seven isolates from aquatic environments. In this study we extended our search to other environments such as wood chip mulch, soil, and sediments from mangrove swamps. We were able to isolate and characterize 2...

Perkey, David Wayne

The Earth s continental margins are currently<br>the primary site of organic carbon burial. Over<br>geologic time the burial and preservation of<br>organic carbon plays a significant role in<br>regulating atmospheric composition. The<br>efficiency at which organic carbon is buried is<br>influenced by many factors that include dissolved<br>oxygen levels, sedimentation rates, and organic<br&amp...

Johansson, Anna Maria

Continuous rate infusion (CRI) of furosemide is considered a superior method of administration to intermittent administration (IA) in humans. This study examined whether furosemide CRI, compared to IA, would increase diuretic efficacy with decreased fluid and electrolyte fluctuations and activation of the renin-angiotensin-aldosterone system (RAAS) in the horse.Five mares were used in a crossover design study. During a 24-hour period each horse received a total of 3 mg/kg furosemide by either CR...

Menon, Surabi

<p> Aerosols affect the radiation budget of the earth-atmosphere system by directly reflecting or absorbing solar radiation and also indirectly, by altering the cloud albedo through changes in the cloud condensation nuclei concentration (CCN). Increases in CCN concentrations result in an increase in the cloud droplet number concentration (N). Assuming the cloud liquid water content (LWC) stays the same, this will result in smaller cloud droplet sizes. Thus, this will increase cloud...

Parker, Douglas S.

<p>PARKER, DOUGLAS SEABROOK.Using Botanical Analysis to Shape aLongleaf Restoration Project. (Under the direction of Gary Blank.)<p> This thesis focuses on the rare and endangered Piedmont TransitionalLongleaf Pine Community (PTLC) found on the Harris Research Tract (HRT)located in southern Wake County, North Carolina. The goal of this thesis is to laya foundation of knowledge to guide the restoration and preservation of the PTLC. This guidance is via three different ...

YU, SHAOCAI

<p>The Intergovernmental Panel on Climate Change (IPCC) has reported that in the southeastern US and eastern China, the general greenhouse warming due to anthropogenic gaseous emissions is dominated by the cooling effect of anthropogenic aerosols. To verify this model prediction in eastern China and southeastern US, we analyzed regional patterns of climate changes at 72 stations in eastern China during 1951-94 (44 years), and at 52 stations in the southeastern US during 1949-94 (46...

Joshi, Sandesh Surendra

<p>In the woodworking industry, drilling (boring) is one of the most extensively used processes. Due to the traditional nature of the woodworking industry, not much data on machining has been recorded, only a fraction of this on drilling. This lack of information hinders the understanding and thus improvement in the process of drilling. The objective of this research is to provide a pilot study on chip clogging and the surface finish generated while drilling wood and also to examin...

Barlow, Steven Todd

<p>The effects of changes in elevation, route distance, route complexity, and non-spatial information on memory for a virtual environment were investigated. Thirty college students learned the layout of a two-story virtual environment through a series of navigation tasks. Participants were required to learn the route from a starting point to each of 14 rooms in the environment. After completing six blocks of learning trials, the participants estimated route distances and directions...

Belonger, Paul J.

<p>BELONGER, PAUL JAMES. Variation of selected juvenile wood properties in four southern provenances of loblolly pine. (Under the direction of Steven E. McKeand.)Gravimetric wood density, x-ray densitometry, and latewood tracheids were used to investigate the relative importance of genetic and environmental effects on various assessments of wood density, tracheid characteristics, and growth traits in loblolly pine (Pinus taeda L.). Breast-height wood samples were taken from four 12...

Aris, Virginie Marie

<p>Weather based models help time fungicide applications to the periods when the diseases are most likely to occur. The first objective of this work was to compare and adapt weather-based advisories developed for the control of Cercospora arachidicola on peanuts for resistant cultivars. It was achieved by comparing the disease progress curves of the 1997-1999 growing seasons in Lewiston NC, to spray schedules simulated by the Virginia Advisory, the Parvin, Smith and Crosby Advisory...

Roswintiarti, Orbita

<p>The purpose of the research has been to provide a better understanding of the climatology, variability, mechanisms, physical processes, and predictability of the Intertropical Convergence Zone (ITCZ), one of the most prominent and important features of the tropical atmosphere. The effort is focused on six different tasks based on statistical and numerical methods. Analysis of the mean and meridional profile of the global ITCZ suggests that each tropical ocean domain has differen...

Kegley, Angelia Joyce

<p>Seedlings of 60 loblolly pine (Pinus taeda L.) families representing four populations, Atlantic Coastal, Piedmont, Coastal x Piedmont, and Piedmont x Coastal were compared for early seedling growth and cold hardiness. The objectives of this study were to examine seedling growth of the four populations in a greenhouse environment and cold hardiness of the four populations in controlled environments (preconditioning) designed to mimic environmental conditions in the Piedmont areas...

BANG, JISU

<p>The solubility of heavy metal (trace metal) contaminants in soils depends on metal concentration, chemical speciation, and conditions such as pH, redox potential, and ionic strength of the soil solution. The objective of this study was to determine the dissolution (potential mobilization) of metal contaminants in response to induced changes in pH and redox potential in soils surrounding abandoned incinerators at two outlying US Marine Corps air fields: MCALF-Bogue and MCOLF-Atla...

Reina, Laura D.

ABSTRACTREINA, LAURA D. Biocontrol of Listeria monocytogenes in minimally processed brined refrigerated cucumbers (Under the direction of Henry Fleming and Fred Breidt)The purpose of the research has been to develop a biocontrol model system for the inhibition of Listeria monocytogenes (pathogen) in minimally processed fruits and vegetables to improve their safety. One application of this model was to evaluate the potential use of a bacteriocin-producer Lactococcus lactis or bacteriocin-nonprodu...

Karoly, Cynthia Bell

ABSTRACTKAROLY, CYNTHIA BELL. Epilithic diatom assemblages in headwater streams of North Carolina and Virginia. (Under the direction of James Gregory.)Using data collected by the Environmental Protection Agency during synoptic sampling for the Environmental Monitoring and Assessment Program, I studied the quantitative composition of diatom communities in 112 samples distributed in first through third-order streams within the Blue Ridge, Southeastern Plain, Coastal Plain and Piedmont ecoregions o...

Bacheler, Nathan Mitchell

<p>The bigmouth sleeper Gobiomorus dormitor is an eleotrid species found in southernFlorida and Texas, along the Atlantic coast of Central and South America, and theCaribbean Islands. This species is important in terms of recreational and consumptivefishing, and conservation. Bigmouth sleepers are harvested by anglers in parts of their range, while in Florida hydrological changes, habitat loss, and reduced waterquality have reduced the species already small geographical distributio...

Peng, Machuan

<p>PENG, MACHUAN. A numerical modeling study of the hydrodynamics of the Croatan-Albemarle-Pamlico Estuary System, North Carolina. (Under the direction of Lian Xieand Frederick Bingham)Numerical studies in the Croatan-Albemarle-Pamlico Estuary System (CAPES),are urgently needed for water quality control, environment protection and disastermitigation. In this study, a three-dimensional primitive equation hydrostatic model withhigh horizontal resolution is configured for the CAPES an...

Reed, Meredith Lynn

Dilute magnetic semiconductors Mn:GaN and Mn:InGaN showing ferromagnetic behavior at room temperature and above were achieved. Light emitting diode devices doped with Mn via diffusion produced operational devices with ferromagnetic properties at room temperature.Mn:GaN films were grown by: Mn diffusion into metal organic chemical vapor deposition (MOCVD) grown GaN; ion implantation of Mn into MOCVD grown GaN substrates; and MOCVD growth of Mn:GaN using (Et,Cp)<sub>2</sub&amp...

Mallinson, Christine

<p>Recent studies of bi-ethnic enclave communities in coastal North Carolina (e.g., Wolfram, Thomas, and Green 2000) suggest that earlier African American speech both accommodated localized dialect norms and also exhibited a persistent substratal effect from the early African-European contact situation. To determine if such situations were the norm or an anomaly, this study examines Beech Bottom, North Carolina, a long-term, bi-ethnic enclave mountain community. In the early 1900s,...

Daley, Salinda Siobhan

<p>In the United States, where private land predominates, most conservation and management efforts have focused on publicly owned land, likely due to conflicting traditions of private property rights, public ownership of wildlife, and state regulation of wildlife. At present, property rights are increasingly juxtaposed with stewardship responsibilities and there is increasing pressure to blend public and private land management. In the southeastern United States, early successional...

Tarant, Stephanie Ann

<p>Today s labor force is more mobile than any cohort in recent history. Labor force mobility and state level retention can have profound effects on the economy of a state. It is necessary for organizations to both effectively retain their own talent as well as to attract top talent from other states. Understanding the individual level factors that predict who will move and who will stay in-state after graduating from college is important for policy makers and organizations looking...

Goodnight, Dana Jon

GOODNIGHT, DANA JON. Impact of a large sphere into a bed of cohesionless particles. (Under the direction of David Genereux)Impact and penetration of a large sphere into both dry and water-saturated granular beds of smaller particles were studied using physical and numerical experiments. In both sets of experiments the impacting sphere displays characteristic deceleration curves that may be used to infer the geotechnical and sedimentological character of the granular bed. Quantitative comparison ...

Sivagnanam, Subhashini

<i>The main goal of parallelization is speed up. As the number of processors increases, there is a little or no speedup, since a performance threshold is reached for a fixed problem size. This is because scalability for a parallel program is limited by the communication and synchronization overhead. Slipstream multiprocessor runs two redundant copies of the same program in a chip multiprocessor, where one program runs ahead of the other. The leading program is called the A-Stream a...

Webb, Elizabeth Lynn

The purpose of this research was to define the critical process control parameters that influence texture and yield for the precook unit operation in the commercial canning of Skipjack tuna. To accomplish this goal, the impact of precook temperature and time combinations on the Instrumental Texture Profile Analysis (ITPA) texture parameters, protein state, weight loss, and moisture content of hydrothermally treated tuna loin meat was investigated. It was found that temperature was the primary in...

Bucci, John P

Eutrophication is increasing in estuaries as a result of anthropogenic activity along the land-sea margin. Human activities contribute large amounts of nitrogen and carbon compounds to watersheds, resulting in changes in resource availability through alteration of biogeochemical cycles. Although the effects of poor water quality on lower trophic level biota is well understood, the impact of nutrient waste on upper trophic levels, such as blue crabs (<I>Callinectes</I>...