5218
博碩士論文
purple acid phosphatase, metallo β lactamase, ketol acid reductoisomerase, kinetics, x-ray crystallography, metal dependent enzymes, binuclear metallohydrolases
Metalloproteins account for at least half of all known proteins. Metal ions often facilitate chemical that are energetically and/or kinetically challenging. Metal ion-dependent proteins are responsible for a myriad of essential biological functions, including respiration, biosynthesis of essential amino acids, nitrogen fixation, oxygen transport, photosynthesis and metabolisms (e.g. glycolysis and citric acid cycle). Not surprisingly, a growing number of disorders (e.g. various cancers, phenylke...