Paula Pegado, and Felipe Alckmin-Carvalho, and Danielle Leme, and Francisca Carneiro, and Patrícia Kypriotis, and Priscila Camacho, and Bacy Fleitlich-Bilyk

Abstract Background: Most of the clinical trials involving cognitive-behavioral therapy (CBT) for the treatment of anorexia nervosa (AN) used the individual therapy format, and few have been dedicated to adapting and assessing the effects of the group format. Objectives: To assess the applicability and effects of a group CBT program for Brazilian adolescents with AN. Methods: Open clinical trial with 22 patients with AN divided into an intervention group – IG (n = 11; CBT, psychiatry, nutriti...

Kawtar Kettani, and Joel Moubayed-Breil

Based on a large material collected during the last two decades in 43 sites covering a wide range of habitats (fresh and brackish water) we delimited four ecological zones, which extend between sea level and high mountain areas located above 1000 m. The four ecological zones are: Zone 1 (Estuarine zone including pools, ponds, lagoons and wet meadows, altitude 0-10 m); Zone 2 (Potamal, alt. 10-350 m); Zone 3 (Lower basin of streams and wadis (alt. 350-1000 m); Zone 4 (Upper basin of streams, wad...

Linjian WU, and Yuanzhan WANG, and Zhong XIAO, and Yi LI

Mobile offshore base (MOB) was treated as a research object, and a simplified algorithm was developed for determining the dynamic constraint forces on flexible connectors of MOB at rough sea states. The algorithm was adopted to calculate and analyze the fluctuation laws between dynamic constraint forces and different parameters. The wave loads on MOB structures were evaluated based on the revised Morison equation instead of potential flow theory, and the conventional computational methods were s...

N.-J. Schlegel, and H. Seroussi, and M. P. Schodlok, and E. Y. Larour, and C. Boening, and D. Limonadi, and M. M. Watkins, and M. Morlighem, and M. R. van den Broeke

<p>Estimating the future evolution of the Antarctic Ice Sheet (AIS) is critical for improving future sea level rise (SLR) projections. Numerical ice sheet models are invaluable tools for bounding Antarctic vulnerability; yet, few continental-scale projections of century-scale AIS SLR contribution exist, and those that do vary by up to an order of magnitude. This is partly because model projections of future sea level are inherently uncertain and depend largely on the model's boundary cond...

Sakamoto Masaya, and Nishimura Rimei, and Irako Taiga, and Tsujino Daisuke, and Ando Kiyotaka, and Utsunomiya Kazunori

<p>Abstract</p> <p>Background</p> <p>No previous studies have compared the DPP-4 inhibitors vildagliptin and sitagliptin in terms of blood glucose levels using continuous glucose monitoring (CGM) and cardiovascular parameters.</p> <p>Methods</p> <p>Twenty patients with type 2 diabetes mellitus were randomly allocated to groups who received vildagliptin then sitagliptin, or vice versa. Patients were hospitalized at 1 month after starting each drug, and CGM was used to determine: 1) mean (± standa...

Henriksen K, and Bay-Jensen AC, and Byrjalsen I, and Karsdal MA, and Riis BJ, and Christiansen C

<p>Abstract</p> <p>Background</p> <p>Osteoarthritis (OA) involves changes in both bone and cartilage. These processes might be associated under some circumstances. This study investigated correlations between bone and cartilage degradation in patients with OA as a function of sex, Kellgren-Lawrence (KL) score, Body Mass Index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation.</p> <p>Methods</p> <p>This study was a 2-week, double-blind, double-dummy, randomized study including 3...

Schwantes Elizabeth A, and Nyenhuis Sharmilee M, and Mathur Sameer K

Oludolapo Ola Afuwape, and Omobolaji O Ayandipo, and Modupe Kuti, and T A Adigun, and O K Idowu

Context: Peritonitis induces an inflammatory response characterized by the elevation of various cytokine levels. Included in this cascade of cytokines are tumor necrosis factor-alpha (TNF-α) and interleukin-1 alpha (IL-1α). The outcome of patient care may be associated with the pattern of elaboration of these cytokines. Aim: The aim of this study was to describe the pattern of cytokine response (TNF-α and IL-1α) in the course of peritonitis and evaluate them as predictors of mortality in periton...

M. Kirthiga, and M. S. Muthu, and G. Kayalvizhi, and C. Krithika

Background: Interproximal contact areas in primary teeth are known to be broader, flatter, and situated more gingivally than in permanent teeth. The objective of the present study was to evaluate the different types of intact interproximal contact areas in primary teeth using cone beam computed tomography (CBCT) among children. Methods: A cross-sectional study was designed with 74 contacts from 28 existing CBCT images of children aged between 3 and 14 years, obtained from the Indian Dental Educa...

Stephenson Richard, and Hough Elaine, and Swift Louise

<p>Abstract</p> <p>Background</p> <p>Clinical guidelines for the management of back pain frequently recommend 'manual therapy' as a first line intervention, with psychosocial screening and 'active rehabilitation' for those not improving at 6 weeks post onset. The potential for psychosocial factors to predict treatment response and therefore outcome has not been adequately explored. The purpose of this pilot study was to determine the feasibility of a study to compare manual therapy and active re...

Khayef Golandam, and Young Julia, and Burns-Whitmore Bonny, and Spalding Thomas

<p>Abstract</p> <p>Background</p> <p>Given that acne is a rare condition in societies with higher consumption of omega-3 (n-3) relative to omega-6 (n-6) fatty acids, supplementation with n-3 may suppress inflammatory cytokine production and thereby reduce acne severity.</p> <p>Methods</p> <p>13 individuals with inflammatory acne were given three grams of fish oil containing 930 mg of EPA to their unchanged diet and existing acne remedies for 12 weeks. Acne was assessed using an overall severity ...

Rasmussen, Peter, and Petersen, Kaj Strand, and Ryves, David B.

Kay Thurley, and Ulrike Schild

Abstract Navigation crucially depends on the capability to estimate time elapsed and distance covered during movement. From adults it is known that magnitude estimation is subject to characteristic biases. Most intriguing is the regression effect (central tendency), whose strength depends on the stimulus distribution (i.e. stimulus range), a second characteristic of magnitude estimation known as range effect. We examined regression and range effects for time and distance estimation in eleven-yea...

Sandro Gelsomino, and Daniel M. Johnson, and Roberto Lorusso

Merle Lewer, and Joachim Kosfelder, and Johannes Michalak, and Dorothea Schroeder, and Nadia Nasrawi, and Silja Vocks

Abstract Background Although not part of the diagnostic criteria of the DSM-5, body image disturbance seems to be a relevant feature of Binge Eating Disorder (BED) as well as of other eating disorders such as Anorexia Nervosa (AN) or Bulimia Nervosa (BN). Hence, the aim of the present pilot study was to assess the changeability of body image disturbance in a sample of overweight females with BED by a cognitive-behavioral treatment, directly addressing body image disturbance. Method Overweight fe...

Alexey Kashevnik, and Nikolay Teslya, and Nikolay Shilov

The paper describes a logistic service-based approach to real-time ridesharing based on smartspace concept. Smart-M3 information platform is used as smart space infrastructure for presented approach. The service is based on Smart-M3 RDF ontology which is formed by ontology slices of participants' mobile devices. The paper presents an algorithm for finding appropriate fellow- travelers for drivers as well as definition of acceptable pick-up and drop-off points for them.

M. González-Rivero, and A. R. Harborne, and A. Herrera-Reveles, and Y.-M. Bozec, and A. Rogers, and A. Friedman, and A. Ganase, and O. Hoegh-Guldberg

Abstract Structural complexity strongly influences biodiversity and ecosystem productivity. On coral reefs, structural complexity is typically measured using a single and small-scale metric (‘rugosity’) that represents multiple spatial attributes differentially exploited by species, thus limiting a complete understanding of how fish associate with reef structure. We used a novel approach to compare relationships between fishes and previously unavailable components of reef complexity, and contras...

Bernard Kakuhikire, and Diego Suquillo, and Elly Atuhumuza, and Rumbidzai Mushavi, and Jessica M. Perkins, and Atheendar S. Venkataramani, and Sheri D. Weiser, and David R. Bangsberg, and Alexander C. Tsai

HIV and poverty are inextricably intertwined in sub-Saharan Africa. Economic and livelihood intervention strategies have been suggested to help mitigate the adverse economic effects of HIV, but few intervention studies have focused specifically on HIV-positive persons. We conducted three pilot studies to assess a livelihood intervention consisting of an initial orientation and loan package of chickens and associated implements to create poultry microenterprises. We enrolled 15 HIV-positive and 2...

E. Lovecchio, and N. Gruber, and M. Münnich

<p>Several studies in upwelling regions have suggested that mesoscale structures, such as eddies and filaments, contribute substantially to the long-range transport of the organic carbon from the nearshore region of production to the offshore region of remineralization. Yet a comprehensive analysis of this mesoscale flux and of its impact across the Canary Upwelling System (CanUS) has not been provided. Here, we fill this gap using simulations with the Regional Oceanic Modeling System (ROM...

Jouili, S., and Semprucci, F., and Nasri, A., and Saidi, I., and Mahmoudi, E., and Essid, N.

A detailed inventory of the free-living nematodes of Tunisia has been made for the northern part of Tunisia, but the southern part of the country is unexplored. El Bibane is the second largest lagoon in Tunisia. It is thus of high importance for future conservation actions, but little is known about its biodiversity. In this study, we identified 71 nematode species, belonging to 68 genera and 22 families. Richness was lowest in the central area of the lagoon where the highest percentages of mud ...

I. Hernández-Carrasco, and L. Solabarrieta, and A. Rubio, and G. Esnaola, and G. Esnaola, and E. Reyes, and A. Orfila

<p>High-frequency radar, HFR, is a cost-effective monitoring technique that allows us to obtain high-resolution continuous surface currents, providing new insights for understanding small-scale transport processes in the coastal ocean. In the last years, the use of Lagrangian metrics to study mixing and transport properties has been growing in importance. A common condition among all the Lagrangian techniques is that complete spatial and temporal velocity data are required to compute traje...

Kazuki Takahashi, and Toshiaki Tsunogae, and Emmanuel Nwachukwu Ugwuonah

We report new petrological, phase equilibria modeling, and fluid inclusion data for pelitic and mafic granulites from Rundvågshetta in the highest-grade region of the Neoproterozoic Lützow-Holm Complex (LHC), East Antarctica, and provide unequivocal evidence for fluid-rock interaction and high-temperature metasomatism in the presence of brine fluid. The studied locality is composed dominantly of well-foliated pelitic granulite (K-feldspar + quartz + sillimanite + garnet + ilmenite) with foliatio...

Pérez Pilar, and Hernández-Inda Zaira L, and Carballo José, and García-Grávalos María D

<p>Abstract</p> <p>Background</p> <p>The brine shrimp lethality assay is considered a useful tool for preliminary assessment of toxicity. It has also been suggested for screening pharmacological activities in plant extracts. However, we think that it is necessary to evaluate the suitability of the brine shrimp methods before they are used as a general bio-assay to test natural marine products for pharmacological activity.</p> <p>Material and Methods</p> <p>The bioactivity of the isopropanolic (2...

Yousuf Basit, and Sanadhya Payal, and Keshri Jitendra, and Jha Bhavanath

<p>Abstract</p> <p>Background</p> <p>Soils harbour high diversity of obligate as well as facultative chemolithoautotrophic bacteria that contribute significantly to CO₂ dynamics in soil. In this study, we used culture dependent and independent methods to assess the community structure and diversity of chemolithoautotrophs in agricultural and coastal barren saline soils (low and high salinity). We studied the composition and distribution of chemolithoautotrophs by means of functional m...

Galatchi Liviu-Daniel

Moreno José, and Ramos-Elorduy Julieta, and Camacho Victor

<p>Abstract</p> <p>Anthropoentomophagy is an ancient culinary practice wherein terrestrial and aquatic insects are eaten by humans. Of these species of insects, terrestrial insects are far more commonly used in anthropoentomophagy than aquatic insects. In this study we found that there are 22 genera and 78 species of edible aquatic beetles in the world. The family Dytiscidae hosts nine genera, Gyrinidae one, Elmidae two, Histeridae one, Hydrophilidae six, Haliplidae two and Noteridae one. Of the...

Noriaki Sagata, and Takahiro A. Kato, and Shin-ichi Kano, and Masahiro Ohgidani, and Norihiro Shimokawa, and Mina Sato-Kasai, and Kohei Hayakawa, and Nobuki Kuwano, and Ashley M. Wilson, and Koko Ishizuka, and Shiori Kato, and Takeshi Nakahara, and Makiko Nakahara-Kido, and Daiki Setoyama, and Yasunari Sakai, and Shouichi Ohga, and Masutaka Furue, and Akira Sawa, and Shigenobu Kanba

Abstract Direct conversion technique to produce induced-neuronal (iN) cells from human fibroblasts within 2 weeks is expected to discover unknown neuronal phenotypes of neuropsychiatric disorders. Here, we present unique gene expression profiles in iN cells from patients with neurofibromatosis type 1 (NF1), a single-gene multifaceted disorder with comparatively high co-occurrence of autism spectrum disorder (ASD). Microarray-based transcriptomic analysis on iN cells from male healthy controls an...

Helene Børretzen Fjørtoft, and Francois Besnier, and Anne Stene, and Frank Nilsen, and Pål Arne Bjørn, and Ann-Kristin Tveten, and Bengt Finstad, and Vidar Aspehaug, and Kevin Alan Glover

Abstract The parasitic salmon louse, and its resistance to chemical delousing agents, represents one of the largest challenges to the salmon aquaculture industry. We genotyped lice sampled from wild salmon and sea trout throughout Norway with the recently identified Phe362Tyr mutation that conveys resistance to organophosphates. These results were compared to data from lice sampled on farmed salmon in the same regions. The resistant (R) allele was observed in salmon lice from wild salmon and sea...

Kevin M. Johnson, and Gretchen E. Hofmann

Abstract Background Ocean acidification (OA), a change in ocean chemistry due to the absorption of atmospheric CO2 into surface oceans, challenges biogenic calcification in many marine organisms. Ocean acidification is expected to rapidly progress in polar seas, with regions of the Southern Ocean expected to experience severe OA within decades. Biologically, the consequences of OA challenge calcification processes and impose an energetic cost. Results In order to better characterize the response...

Michael Clarke, and Vanessa Hogan, and Deborah Buck, and Jing Shen, and Christine Powell, and Chris Speed, and Peter Tiffin, and John Sloper, and Robert Taylor, and Mahmoud Nassar, and Kerry Joyce, and Fiona Beyer, and Richard Thomson, and Luke Vale, and Elaine McColl, and Nick Steen

Introduction: The evidence base for the treatment of strabismus (squint) is poor. Our main aim is to improve this evidence base for the treatment of a common type of childhood squint {intermittent exotropia, [X(T)]}. We conducted an external pilot study in order to inform the design and conduct of a future full randomised controlled trial (RCT). Methods: Children of between 6 months and 16 years with a recent diagnosis of X(T) were eligible for recruitment. Participants were recruited from secon...

Seinen Chow, and Nobuaki Suzuki, and Yoji Nakamura, and Motoshige Yasuike, and Kenji Saitoh, and Takashi Yanagimoto

Abstract Nucleotide sequences of four distinct calmodulin genes (designated as CaM-A to -D) of the Pacific bluefin tuna (Thunnus orientalis) were compared. Nucleotide sequence divergence between the coding regions of four genes ranged from 16.0 to 21.6%, and locus-specific eight primer pairs targeting introns were designed. These primer pairs amplified expected size of fragments in five congeneric tuna species, and utility of these primer pairs was investigated using distant fish species.

Ochi Hideki, and Katsumi Yasukazu, and Hirota Satoko, and Itoh Kazunori, and Kitakoji Hiroshi

<p>Abstract</p> <p>Background</p> <p>The present study tests whether a combined treatment of acupuncture and transcutaneous electrical nerve stimulation (TENS) is more effective than acupuncture or TENS alone for treating knee osteoarthritis (OA).</p> <p>Methods</p> <p>Thirty-two patients with knee OA were randomly allocated to four groups. The acupuncture group (ACP) received only acupuncture treatment at selected acupoints for knee pain; the TENS group (TENS) received only TENS treatment at pa...

Uchenna Okafor, and Rik Crutzen, and Ifeanyi Okekearu, and Sylvia Adebajo, and Adaora Uzoh, and Egbe Aneotah Awo, and Chukwuemeka Chima, and Ogechukwu Agwagwa, and Bart van den Borne

Abstract Background The HIV prevalence among female populations involved in sex work in Nigeria has heightened interest in HIV prevention programming for this sub-population with brothel-based female sex workers (BB FSWs) having a prevalence of 27.4%, six times higher than the prevalence in the general population. Methods/design The clusters in the randomized pilot trial will be brothels and female sex workers (FSWs) residing in the brothels will be the participants of the study. The participant...

Sohair R. Fahmy, and Mahmoud A. Amer, and Mohannad H. Al-killidar

Holothuria arenicola is the most important and abundant sea cucumber species in the Mediterranean Sea on the Egyptian coast. This work aimed to investigate the prophylactic and the curative effects of H. arenicola extract HaE (200 mg/kg) on gastric mucosal damage following indomethacin and cold stress in healthy rats. Sixty-four rats were randomly divided into four main groups. Rats of the first group (8 rats/group) were administered distilled water orally (control group), rats of the second gro...

Tülin ÇOKER, and Okan AKYOL

In this review, updated check-list of marine fish in the Bay of Saroz, northern Aegean Sea was presented. From the results of relevant studies by the coastal fisheries and trawls in Saroz Bay, we therefore determined totally 280 fish species, belonging to 96 families. Coastal fisheries in Saroz Bay consist of small scale such as gillnet, trammel net, longline and handline fisheries, while the large scale fisheries is very limited.

Mark W. Vander Weg, and Ashley J. Cozad, and M. Bryant Howren, and Margaret Cretzmeyer, and Melody Scherubel, and Carolyn Turvey, and Kathleen M. Grant, and Thad E. Abrams, and David A. Katz

Abstract Background Tobacco use remains prevalent among Veterans of military service and those residing in rural areas. Smokers frequently experience tobacco-related issues including risky alcohol use, post-cessation weight gain, and depressive symptoms that may adversely impact their likelihood of quitting and maintaining abstinence. Telephone-based interventions that simultaneously address these issues may help to increase treatment access and improve outcomes. Methods This study was a two-gro...

Esther Sebastian-Gonzalez, and José Antonio Sanchez-Zapata, and Joan Navarro, and Antonio Delgado, and Francisco Botella

Different factors can affect the isotopic values of aquatic organisms. Nevertheless, water quality may be very important for aquatic organisms because they directly depend on it. In this article, we aimed to investigate if variations in the chemical and biological water characteristics affect the stable isotope values of aquatic organisms. We also wished to discuss alternative sources of isotopic variability. We analysed the water chemical characteristics, the input of extra nitrates from bird g...

JORGE VALDÉS, and DOMINGO ROMÁN, and PAOLA DÁVILA, and LUC ORTLIEB, and MARCOS GUÍÑEZ

Entre junio de 2002 y abril de 2003 se midió el contenido de cadmio total y disuelto entre la superficie y los 100 m de profundidad, en dos estaciones localizadas en la bahía Mejillones del Sur. El rango de cadmio total y cadmio disuelto en las aguas de esta bahía fue 0,41-10,7 y 0,08-1,61 nM, respectivamente, durante el período de muestreo. Los resultados fueron correlacionados con la estructura físico-química de la columna de agua al momento del muestreo, de manera de estudiar los patrones de ...

Moravec František, and Justine Jean-Lou

Based on light and scanning electron microscopical studies of nematode specimens from the digestive tract of some rarely collected anguilliform and perciform fishes off New Caledonia, three new species of Cucullanus Müller, 1777 (Cucullanidae) are described: C. austropacificus n. sp. from the longfin African conger Conger cinereus (Congridae), C. gymnothoracis n. sp. from the lipspot moray Gymnothorax chilospilus (Muraenidae), and C. incognitus n. sp. from the seabream Dentex fourmanoiri (Sparid...

Robert W. Boessenecker, and Jonathan H. Geisler

The stem odontocete Agorophius pygmaeus (Ashley Formation, lower Oligocene, South Carolina; 29.0–26.57 Ma) has been a critical point of comparison for studies of early neocete evolution owing to its early discovery as well as its transitional anatomy relative to archaeocete whales and modern odontocetes. Some time during the late nineteenth century the holotype skull went missing and has never been relocated; supplementary reference specimens have since been recently referred to the species from...

Knutson Keith L, and Piechocki Marie P, and Erskine Courtney, and Wei Wei Z, and Charo Jehad, and Poschke Isabel, and Norell Håkan, and Bergh Jonas, and Lidbrink Elisabet, and Kiessling Rolf

<p>Abstract</p> <p>Background</p> <p>Adjuvant trastuzumab (Herceptin) treatment of breast cancer patients significantly improves their clinical outcome. Vaccination is an attractive alternative approach to provide HER-2/neu (Her2)-specific antibodies and may in addition concomitantly stimulate Her2-reactive T-cells. Here we report the first administration of a Her2-plasmid DNA (pDNA) vaccine in humans.</p> <p>Patients and Methods</p> <p>The vaccine, encoding a full-length signaling-deficient ver...

La Manna Alessio, and Sanfilippo Alessandra, and Capodanno Davide, and Salemi Antonella, and Polizzi Gesualdo, and Deste Wanda, and Cincotta Glauco, and Cadoni Alessandra, and Marchese Anna, and Figuera Michele, and Ussia Gian P, and Pittalà Rosetta, and Privitera Carmelo, and Tamburino Corrado

<p>Abstract</p> <p>Background</p> <p>Before trans-catheter aortic valve implantation (TAVI), assessment of cardiac function and accurate measurement of the aortic root are key to determine the correct size and type of the prosthesis. The aim of this study was to compare cardiovascular magnetic resonance (CMR) and trans-thoracic echocardiography (TTE) for the assessment of aortic valve measurements and left ventricular function in high-risk elderly patients submitted to TAVI.</p> <p>Methods</p> <...

Wilson Sue, and Holder Roger L, and Roalfe Andrea K

<p>Abstract</p> <p>Background</p> <p>Standardisation of rates in health services research is generally undertaken using the direct and indirect arithmetic methods. These methods can produce unreliable estimates when the calculations are based on small numbers. Regression based methods are available but are rarely applied in practice. This study demonstrates the advantages of using logistic regression to obtain smoothed standardised estimates of the prevalence of rare disease in the presence of c...

Moineddin Rahim, and Matheson Flora I, and Glazier Richard H

<p>Abstract</p> <p>Background</p> <p>Many studies conducted in health and social sciences collect individual level data as outcome measures. Usually, such data have a hierarchical structure, with patients clustered within physicians, and physicians clustered within practices. Large survey data, including national surveys, have a hierarchical or clustered structure; respondents are naturally clustered in geographical units (e.g., health regions) and may be grouped into smaller units. Outcomes of ...

Funkenstein Bruria, and Nadjar-Boger Elisabeth

<p>Abstract</p> <p>Background</p> <p>Myostatin (MSTN) is a member of the transforming growth factor-ß superfamily that functions as a negative regulator of skeletal muscle development and growth in mammals. Fish express at least two genes for <it>MSTN</it>: <it>MSTN-1 </it>and <it>MSTN-2</it>. To date, <it>MSTN-2 </it>promoters have been cloned only from salmonids and zebrafish.</p> <p>Results</p> <p>Here we described the cloning and sequence analysis of <it>MSTN-2 </it>gene and its 5' flanking ...

Xiang Li-xin, and He Ding, and Dong Wei-ren, and Zhang Yi-wen, and Shao Jian-zhong

<p>Abstract</p> <p>Background</p> <p>Systematic research on fish immunogenetics is indispensable in understanding the origin and evolution of immune systems. This has long been a challenging task because of the limited number of deep sequencing technologies and genome backgrounds of non-model fish available. The newly developed Solexa/Illumina RNA-seq and Digital gene expression (DGE) are high-throughput sequencing approaches and are powerful tools for genomic studies at the transcriptome level....

Alexander Tyukin, and Ilya Lebedev, and Andew Priorov

This work describes a new approach to the mobile robot orientation in space and its obstacle determination. The method uses color beacons placed on the environmental objects for position determination. For obstacle detection the computer vision algorithm is used. All the system functions using one single camera. Both algorithms developed are investigated under different conditions.

Kirsten J. Coppell, and Sally L. Abel, and Trish Freer, and Andrew Gray, and Kiri Sharp, and Joanna K. Norton, and Terrie Spedding, and Lillian Ward, and Lisa C. Whitehead

Abstract Background Primary care nurse-led prediabetes interventions are seldom reported. We examined the implementation and feasibility of a 6-month multilevel primary care nurse-led prediabetes lifestyle intervention compared with current practice in patients with prediabetes, with weight and glycated haemoglobin (HbA1c) as outcomes. Methods This study used a convergent mixed methods design involving a 6-month pragmatic non-randomised pilot study with a qualitative process evaluation, and was ...

Jennifer M. Coughlin, and Ting Yang, and Alison W. Rebman, and Kathleen T. Bechtold, and Yong Du, and William B. Mathews, and Wojciech G. Lesniak, and Erica A. Mihm, and Sarah M. Frey, and Erica S. Marshall, and Hailey B. Rosenthal, and Tristan A. Reekie, and Michael Kassiou, and Robert F. Dannals, and Mark J. Soloski, and John N. Aucott, and Martin G. Pomper

Abstract The pathophysiology of post-treatment Lyme disease syndrome (PTLDS) may be linked to overactive immunity including aberrant activity of the brain’s resident immune cells, microglia. Here we used [11C]DPA-713 and positron emission tomography to quantify the 18 kDa translocator protein, a marker of activated microglia or reactive astrocytes, in the brains of patients with post-treatment Lyme disease symptoms of any duration compared to healthy controls. Genotyping for the TSPO rs6971 poly...

Francesca Beilharz, and David J. Castle, and Andrea Phillipou, and Susan L. Rossell

Abstract Background Body dysmorphic disorder (BDD) is a characterised by perceived defects or flaws in appearance which are associated with distressing thoughts, repetitive or obsessive behaviours, and significant impairment in social and occupational functioning. A core feature of BDD involves abnormalities of visual processing, although this is not typically a focus of psychological and psychiatric treatments. While current treatments generally show moderate effectiveness in the short-term, th...